Description

Overview:

Low-dose naltrexone (LDN) refers to using naltrexone at doses between 1.5–4.5 mg, significantly lower than the standard 50 mg dose used for opioid addiction. It is used off-label for autoimmune conditions, chronic pain, and inflammatory disorders.

Mechanism of Action

LDN works by transiently blocking opioid receptors, which leads to a rebound increase in endogenous endorphin production. It also modulates immune system activity by reducing pro-inflammatory cytokines and enhancing regulatory T cells.

Benefits and Indications

• Autoimmune diseases (e.g., Hashimoto’s thyroiditis, lupus, multiple sclerosis)
• Chronic pain conditions (e.g., fibromyalgia, endometriosis, interstitial cystitis)
• Mood disorders and depression

Possible Side Effects

• Vivid dreams or sleep disturbances
• Mild gastrointestinal discomfort
• Fatigue

Drug Interactions

• Opioid medications (blocks their effects)
• Immunosuppressants (potential interaction)