Description

Overview
This compound cream is designed for neuropathic and inflammatory pain. It combines a tricyclic antidepressant (TCA), an anticonvulsant, an NSAID, and a local anesthetic for maximum pain relief.

Mechanism of Action
• Amitriptyline (2%): A TCA that increases serotonin and norepinephrine levels, modulating pain signals.
• Gabapentin (2%): Reduces nerve pain by blocking calcium channels.
• Ketoprofen (10%): NSAID that reduces inflammation.
• Lidocaine (5%): Provides immediate localized pain relief.

Benefits and Indications
• Neuropathic pain – Postherpetic neuralgia, diabetic neuropathy, and chronic nerve pain.
• Inflammatory pain – Osteoarthritis and rheumatoid arthritis.
• Fibromyalgia and myofascial pain syndrome – Reduces muscle and nerve pain.

Possible Side Effects
• Skin irritation – Redness or burning sensation at the site.
• Drowsiness or dizziness – Systemic absorption of amitriptyline and gabapentin.
• Dry mouth and constipation – Due to amitriptyline.
• Potential allergic reaction – Rare but possible.