Description

Overview
Bupropion is an atypical antidepressant used to treat depression, seasonal affective disorder (SAD), and as a smoking cessation aid. Unlike SSRIs, it does not primarily affect serotonin but instead increases dopamine and norepinephrine levels.

Mechanism of Action
Bupropion inhibits the reuptake of dopamine and norepinephrine, leading to improved mood, energy levels, and focus.

Benefits and Indications
• Major depressive disorder (MDD) – Often used when SSRIs cause sexual dysfunction.
• Smoking cessation – Sold as Zyban to reduce nicotine cravings.
• Attention-deficit hyperactivity disorder (ADHD) (off-label) – Can improve focus in some patients.
• Weight-neutral antidepressant – Less likely to cause weight gain compared to SSRIs.

Possible Side Effects
• Insomnia – Often taken in the morning to avoid sleep disturbances.
• Dry mouth and increased heart rate – Common mild effects.
• Seizure risk – Higher doses increase the risk, especially in people with a seizure disorder.
• Agitation or anxiety – Some people feel restless when starting the medication.