Description

Overview

Finasteride is an oral 5-alpha reductase inhibitor primarily used to treat male pattern baldness (androgenetic alopecia) and benign prostatic hyperplasia (BPH). It works by reducing dihydrotestosterone (DHT) levels, a hormone responsible for hair loss and prostate growth.

Mechanism of Action

Finasteride inhibits 5-alpha reductase, an enzyme that converts testosterone into DHT. Since DHT is the main hormone responsible for hair follicle shrinkage and prostate enlargement, reducing its levels helps:

• Prevent hair loss and promote regrowth
• Shrink an enlarged prostate, easing urinary symptoms

Benefits & Indications

1. Hair Loss Treatment

• Helps prevent further hair thinning
• Promotes hair regrowth in some men
• Works best for early-stage male pattern baldness

2. Benign Prostatic Hyperplasia (BPH)

• Reduces prostate size
• Improves urinary flow
• Decreases frequent urination (especially at night)

3. Other Uses

• May be used off-label for hormonal acne and hirsutism (excess hair growth) in women
• Studied for prostate cancer prevention

Possible Side Effects

• Sexual dysfunction (low libido, erectile dysfunction, decreased ejaculation volume)
• Gynecomastia (breast tenderness or enlargement)
• Depression, anxiety, and mood changes
• Dizziness and weakness
• Post-Finasteride Syndrome (PFS): Rare but long-term sexual and psychological side effects after stopping the drug

Drug Interactions

• Alpha-blockers (e.g., Tamsulosin): May increase the risk of low blood pressure
• Testosterone therapy: Reduces effectiveness since TRT increases DHT
• Herbal supplements (Saw Palmetto): May have additive DHT-lowering effects