Description

Overview
Low-dose naltrexone (LDN) is an off-label treatment used for chronic pain, autoimmune diseases, and mental health conditions. It works differently from its high-dose form, which is used for opioid and alcohol dependence.

Mechanism of Action
LDN temporarily blocks opioid receptors, leading to an increase in the body’s natural endorphins. It also modulates neuroinflammation and immune system activity, which may contribute to its effectiveness in depression and anxiety.

Benefits and Indications
• Depression and mood disorders – Enhances endorphin production for natural mood support.
• Chronic pain and fibromyalgia – Reduces pain sensitivity.
• Multiple sclerosis and autoimmune conditions – May regulate immune function.
• PTSD and anxiety – Helps balance the brain’s stress response.

Possible Side Effects
• Vivid dreams or sleep disturbances – Common when starting treatment.
• Mild nausea – Usually temporary.
• Headache and dizziness – Occasional but mild.